These results suggest that the down regulation of cyclin D1, CDK4 and pRb proteins may be related to the effects of cholesterol deficiency on proliferation of Jurkat cells.

• 结果提示，无论是内源性还是外源性胆固醇的缺乏都能抑制Jurkat细胞的增殖，推测这种变化可能与cyclin D1、CDK4及pRb 蛋白表达量的下降而导致相应的cyclin D1/CDK4复合活性下降有关