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- Keywords Epigenetics;Methylation;Genomic imprinting;Chromatin histone modification;CTCF; 表遗传学;甲基化;基因组印记;染色质组蛋白修饰;隔离蛋白;
- Chromatin histone modification 染色质组蛋白修饰
- DNA methylation has an important role in transcriptional regulation, togethering with histone modification and chromatin remodeling. DNA甲基化在基因转录过程中扮有重要角色，并与组蛋白修饰、染色质构型重塑共同参与转录调控。
- Epigenetics refers to the heritable changes in gene expression without any alteration in DNA sequence, including DNA methylation, histone modification and chromatin conformation. 摘要表观遗传学是指基于非基因序列改变所致基因表达水平的变化，如DNA甲基化和组蛋白修饰等；
- Histone modifications such as lysine methylation affect chromatin structure and gene expression. 组蛋白修饰（如赖胺酸残迹的甲基化）能影响染色质结构和基因表达。
- We will further investigate the relationship of histone modification and promoter methylation on the expression of TFPI-2. 今后，我们将在表观遗传层面对TFPI-2基因的修饰和相关组蛋白的修饰进行深入研究。
- DNA hypomethylation,likely to be cooperating with aberrant histone modification,may induce the activation of some T cell genes and development of autoimmunity in SLE. DNA的低甲基化可能在异常组蛋白修饰的协同下引起某些T细胞基因的异常活化,导致狼疮自身免疫的发生。
- The changes of epigenetics such as DNA methylation and histone modification can regulate the expression of genes and play an important role in the development of tumors. 表遗传学改变,如DNA甲基化和组蛋白修饰改变可以调节基因的表达,在肿瘤的发生和发展中可能起关键作用。
- Epigenetics can regulate the transcription of MDR1 gene through the DNA methylation and histone modification,which lead to the high expression of P-gp,causing drug resistance. 最近研究证实，表遗传修饰在调控MDR1基因表达中起重要作用。
- Allis's proposition of the existence of "histone code" enriched our understanding greatly to the genetic information and made the investigation of histone modification a heated field. 摘要组蛋白密码学说提出后，大大丰富了人们对遗传信息的认识，使得组蛋白修饰的研究备受瞩目。
- DNA methylation catalyzed by DNA methyltransferases interacts with histone modification to inhibit gene transcription,induce gene silencing at the participation of many regulators. DNA甲基化由DNA甲基转移酶催化,在多种调节因子的参与下,与组蛋白修饰相互作用,抑制基因转录,导致基因沉默。
- Histone modifications are implicated in influencing gene expression. 组蛋白修饰与影响基因表达有关。
- As a test to determine whether such histone modification functionally affected plasticity, the researchers administered a drug to adult mice that would increase chemical modification of histone. 为了确定组蛋白的化学修饰是否对大脑可塑性产生功能上的影响，研究人员做了一个试验，即给予成年鼠服用一种能够增加组蛋白化学修饰的药物。
- DNA methylation catalyzed by DNA methyltransferases interacts with histone modification to inhibit gene transcription, induce gene silencing at the participation of many regulators. DNA甲基化由DNA甲基转移酶催化 ，在多种调节因子的参与下，与组蛋白修饰相互作用，抑制基因转录，导致基因沉默。
- Keywords Hypertonic stress;Tonicity element binding protein （TonEBP）;Chromatin remodeling;Histone modification; 高渗应激;渗透压反应元件结合蛋白;染色质重塑;组蛋白修饰;
- Chromosome banding patterns are correlated with unique patterns of histone modifications. 染色体带型和组蛋白修饰的特有模式相关。
- Keywords nasopharyngeal carcinoma;epigenetics;DNA methylation;histone modification;chromatin remodeling;genetic regulation by non-coding RNAs;epigenetic molecular marker; 鼻咽癌;表观遗传学;DNA甲基化;组蛋白修饰;染色质重构;非编码RNA调控;表观遗传修饰分子标志物;
- They also concluded that the closure of the critical period was associated with a decrease in the ability of isual experience to drie the histone modifications that are necessary for neural rewiring. 他们同时说道，神经系统的重新架构有赖于组蛋白的化学修饰，而视觉体验刺激产生化学修饰的能力下降与临界期的终止具有相关性。
- This article reviews a number of startling observations about the extent of non-protein-coding RNA transcriptions、DNA methylation and covalent histone modifications in the complex organisms. 拟从非编码RNA、DNA甲基化和组蛋白共价修饰3个层面介绍这方面的研究进展。
- Automatic modification of the index register. 自动修改变址寄存器内容。
