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- Antisese oligodeoxynucleotide 反义寡聚核苷酸
- Objective To study the immunotherapy role of CpG ODN(CpG oligodeoxynucleotide)on tumor. 目的探讨合成含CpG基序的寡核苷酸(CpG ODN)在肿瘤免疫治疗中的研究。
- Methods Phosphorothioate oligodeoxynucleotide containing 2 CpG motifs was synthesized as the adjuvant of HBsAg. 方法以血源HBsAg为接种疫苗,人工合成含CpG基序的硫代磷酸寡脱氧核苷酸作为佐剂,以BALB/e小鼠作为实验动物进行免疫接种;
- PURPOSE To investigate the effects of bcr3/abl2 anisense oligodeoxynucleotide (ASO) on chronic myeloid leukemia (CML). 目的 探讨癌基因bcr_3/abl_2反义寡核苷酸(antisense oligodeoxynucleotide;ASO)对慢性髓细胞白血病(CML)的作用及其作用机理.
- The antisense drug synthesized by DNA synthesizer is an oligodeoxynucleotide (ODN). 由机器合成的反义核酸药物需要有效的纯度鉴定方法。
- Antisense oligodeoxynucleotide technique was used to observe the role of CLC-3 in the effect of ET-1 on BCECs. 采用反义核酸技术，观察CLC-3基因在ET-1对体外培养牛角膜内皮细胞影响中的作用。
- OPC colum provides a high effciency,quick and convenient method for the purification of antisense phosphorothioate Oligodeoxynucleotide to Bcl 2. Bcl- 2硫代反义核酸 OPC纯化法是一种高效、快速、简便的方法
- Objective: To investigate the adjuvant effects of CpG motif-containing oligodeoxynucleotide (CpG) in vitro on human esophageal cancer vaccine. 目的:探讨CpG基序在人食管癌Eca-109细胞疫苗研究中的佐剂效应。
- To study the effect of antisense focal adhesion kinase (FAK) oligodeoxynucleotide on the biological behaviors of U251 MG cells. 目的探讨反义黏着斑激酶(FAK)对U251人胶质瘤细胞株生物学行为影响。
- Objective To study the effect of antisense oligodeoxynucleotide c-myc (c-myc ASODN) on anti-oxidation system in LEC induced by galactose. 目的探讨ASODN对半乳糖性白内障晶体上皮细胞(LEC)中抗氧化系统活力的影响。
- Aim: To observe if bcl-2 antisense oligodeoxynucleotide (ASODN) mediated by jetPEI-RGD improved effect on colon carcinoma cell line caco-2. 目的：观察聚乙烯亚胺(PEI)-整合素蛋白的配体(Arg-Gly-Asp, RGD)介导的bcl-2反义核酸(antisense oligodeoxynucleotide, ASODN)对结肠癌细胞caco-2的作用效果。
- Conclusion ATP7B antisense oligodeoxynucleotide increased the sensitivity of cisplatin in ovarian cancer cell line SKOV3ipl. 结论 ATP7B基因反义寡核苷酸能增加SKOV3ip1细胞对顺铂的敏感性。
- Objectives: To study the inhibitory effects of mouse telomerase RNA (mTR) antisense oligodeoxynucleotide(ASODN) on telomerase activity in rat spermatogonia. 目的 :探讨小鼠端粒酶RNA(mTR)基因的反义寡核苷酸 (ASODN)对体外培养的大鼠A型精原细胞端粒酶活性及其mTR亚基表达的影响。
- Objective To prepare melanoma antigen n(MAGEn)protein vaccine and to investigate the immune responses and anti-tumor effects of MAGE-n protein vaccine accompanied by CpG-containing oligodeoxynucleotide(CpG-ODN)adjuvant. 目的制备人黑色素瘤抗原-n(MAGE-n)蛋白疫苗,研究含CpG基序的寡聚脱氧核苷酸(CpG-ODN)联合MAGE-n蛋白疫苗,诱导小鼠产生的免疫应答,及在肿瘤免疫治疗中的作用。
- Objective: To explore the effect of liposome transfection antisense phosphorothioate oligodeoxynucleotide directed against the coding region of the bcl-2 messenger RNA and the translation site, and G3139 on apoptosis in Raji cells. 目的:通过脂质体分别转染bcl-2两个靶点的反义寡核苷酸(ASODN1、ASODN2)及G3139,观察bcl-2反义寡核苷酸对淋巴瘤细胞株Raji凋亡的影响。
- Objective:To explore the effect of antisense phosphorothioate oligodeoxynucleotide (ASODN) directed against the 5 untranslated region, the translation site and the coding region of the bcl 2 messenger RNA on apoptosis in K562 cells. 目的 :探讨bcl 2不同靶点的反义寡核苷酸 (ASODN)对白血病细胞株K5 6 2细胞凋亡的影响。
- Objective:To investigate the effect of synthetic oligodeoxynucleotide containing CpG motifs (CpG ODN) on antibody production to recombinant hepatitis B surface antigen (rHBsAg) or hepatitis B vaccine respectively. 目的 :探讨合成含CpG基序的寡核苷酸 (CpGODN)对重组乙型肝炎表面抗原 (rHBsAg)及乙型肝炎疫苗增强小鼠特异性抗体产生的效应。
- Objective:To investigate the effects of lymphocyte proliferation using the synthetic oligodeoxynucleotide containing CpG motif(CpG ODN) as immunal adjuvant immunized with the recombinant hepatitis B surface antigen(rHBsAg) in mice. 目的:进一步探讨以合成含CpG基序的寡核苷酸(CpG ODN)作为免疫增强剂与重组乙型肝炎表面抗原(rHB-sAg)联合免疫小鼠,观察其淋巴细胞增殖反应效应。
- Objective:To study the effects of synthetic oligodeoxynucleotide containing CpG motif(CpG ODN) on cell cycle and apoptosis of splenocytes immunized with recombinant hepatitis B surface antigen(rHBsAg). 目的研究合成含CpG基序的寡脱氧核苷酸(CpGODN)对重组乙型肝炎表面抗原(rHBsAg)免疫小鼠脾淋巴细胞细胞周期及细胞凋亡的效应。
- To investigate effects of synthetic oligodeoxynucleotide containing CpG motif (CpG ODN) on specific antibody production and lymphocyte proliferation to recombinant hepatitis B surface antigen (rHBsAg). 目的:探讨合成含CpG基序的寡核苷酸(CpGODN)对重组乙型肝炎表面抗原(rHBsAg)增强小鼠特异性抗体产生及淋巴细胞增殖反应的效应。
