As spermatozoa progress through the epididymis they first acquire the capacity to phosphorylate tyrosine on targets on the principal piece, followed by the midpiece. 精子进入附睾后，它首先获得将精子主段以及中段上的目的蛋白的酪氨酸磷酸化的能力。
These observations suggest that the mutated tyrosine phosphatases are tumor suppressor genes, regulating cellular pathways that may be amenable to therapeutic intervention. 这些观察提示突变的酪氨酸磷酸酶是肿瘤抑制基因，它调节的细胞通路可能会被利用到治疗干预中去。
