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- Short Tandem Repeat in PLA2G4C gene, which can be screened from blood samples, relates to the pathogenesis of glioma. PLA2G4C的短串联重复序列多态性与胶质瘤的发病有一定关系,并可通过血液标本进行此多态性的筛查。
- Objective:To analyze the genetic polymorphism of 9 short tandem repeat(STR) loci on chromosome 7p14-15 in Northeastern China Han population. 目的:分析东北汉族人群中7p14-15区域内9个短串联重复序列(STR)位点的遗传多态性。
- Methods The authors used a set of five Y-specific STR loci which were tetrameric tandem repeat loci chosen from the Genome Database. 方法无血缘关系样本采自成都地区汉族群体。
- Brinkmann B,Klintschar M,Neuhuber F,et al.Mutation rate in human microsatellite:influence of the structure and length of the tandem repeat[J].Am J Hum.Genet,1998,62:1408. 庾蕾;伍新尧;李建金;等.;短串联重复序列遗传突变的观察[M]
- It provides an experiment basis for combining highly genetic specificity of human euchromosome STR (Short Tandem Repeat, STR) with Y- chromosome STR study. 为结合具有高度遗传特异性的人类常染色体及Y染色体短串联重复序列(Short Tandem Repeat, STR)的研究,构建墓葬血亲关系深层次研究奠定了基础。
- A method based on PCR was developed to amplify short tandem repeat(STR) in combination with denaturing gradient gel electrophoresis (DGGE) and silver dyeing. 应用聚合酶链反应扩增STR,经变性凝胶电泳,再用银染显色方法,分析苯丙氨酸羟化酶(PAH)基因内含子3中TCTA重复序列的多态性。
- Allelotype analysis was done at five short tandem repeat markers (D17S855, D17S1322, D17S1323, D17S1326, and D17S1327) in or adjacent to BRCA1 on the recurrent mutation carriers. 对发现携带有相同突变的个体选取5个与BRCA1基因连锁的标记(D17S855、D17S1322、D17S1323、D17S1326和D17S1327)进行单倍型分析。
- Objective To investigate the alleles and genotype frequencies of 6 short tandem repeat (STR) loci DXS7130, DXS1214, DXS6799, DXS6804, DXS7424 and DXS7133 on the X chromosome in Chinese Han individuals living in Shaanxi province of Northwest China. 目的研究陕西西安汉族人群6个位于X染色体上的短串联重复序列DXS7130、DXS1214、DXS6799、DXS6804、DXS7424和DXS7133等位基因及基因型频率分布。
- Objective To investigate the alleles and genotypes frequency of 10 short tandem repeat (STR) loci (DXS101,DXS6789,DXS6799,DXS6804,DXS7130,DXS7132,DXS7133, DXS7423, HPRTB, DXS8378)on X chromosome of Chinese Hui nationality population. 目的研究宁夏回族群体X染色体上的10个短串联重复序列(DXS101、DXS6789、DXS6799、DXS6804、DXS7130、DXS7132、DXS7133、DXS7423、HPRTB、DXS8378)的基因及基因型频率分布。
- ObjectiveTo investigate the relationship between 48bp variant number tandem repeat (VNTR) polymorphism in the third exon of dopamine D 4 receptor(DRD 4) gene and attention deficit hyperactivity disorder (ADHD). 目的 探讨多巴胺D4受体 (dopamineD4receptor,DRD4 )基因 48bp可变重复序列 (variantnumbertandemrepeat,VNTR)多态性与注意缺陷多动障碍(Attention deficithyperactivitydisorder,ADHD)及其相关症状的关系。
- Materials and methods: Polymorphic analysis of MCC, DCC and YNZ22 loci that contain a variable number of tandem repeat(VNTR) was performed in 41 surgical specimens of colorectal carcinoma by the polymerase chain reaction(PCR). 方法:应用多聚酶链反应技术对41例大肠癌MCC、DCC基因和YNZ22位点的数量可变的重复序列(VNTR)区进行了分析。
- Objective:To introduce the application of short tandem repeats in medicine. 目的:介绍短串联重复序列在医学中的应用。
- Methods: Polymorphic analysis of the genetic loci of YNZ22 and DCC containing a variable number of tandem repeat was performed in 46 surgically resected specimens of esophageal carcinoma with PCR. 方法:应用聚合酶链反应技术对46例食管癌YNZ22位点和DCC基因数目可变的串联重复序列(VNTR)区进行了分析。
- Aim:To set up a method of prenatal diagnosis of classic phenylketonuria ( PKU) by linkage analysis of the short tandem repeat(STR) in intron 3 linked to the phenylalanine hydroxylase (PAH) gene. 目的:建立一种利用苯丙氨酸羟化酶(PAH)基因内含子3中短串联重复序列(STR)多态性连锁分析进行经典型苯丙酮尿症(PKU)产前诊断的方法。
- Microsatellites are short tandem repeats widely dispersed through out the eukaryotic genomes, consisting of tandem repeat sequences of 1 to 6 nucleotides. 微卫星(Microsatellite)是一种广泛存在于真核生物基因组中的短的串联重复序列,重复单位一般为1-6个核苷酸。
- Conclusions:Short tandem repeats are the major genetic markers used in medicine. 结论:短串联重复序列是目前医学中应用的主要遗传标记。
- Results:Short tandem repeats were used widely for the study and clinic in medicine. 结果:短串联重复序列已广泛应用于医学临床和研究。
- Conclusion High level expression of epitope from HEV could be achieved by tandem repeats. 结论通过首位串联可以实现HEV线性表位较高效的表达。
- Short tandem repeats (STRs) have been widely used in forensic sciences such as stain analysis and paternity testing. 摘要短串联重复序列(STR)已被广泛应用于法医个体识别和亲子鑑定中。
- Conclusion: The mutation of alleles often exists at the long, highly polymorphic tandem repeats in STRs. 结论:STR基因座的长的、多态性高的串联重复区是等位基因突变的敏感点。