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- p16 gcne p16基因
- Our results indicated that P16 is related to the chondrocyte growth. 结论：P16与软骨细胞的生长调控有关。
- To investigate the role of p16 gene aberrant alteration in pathogenesis and progression of human larynx carcinoma. 目的：探讨p16基因的缺失与人喉癌的发生、发展的关系。
- Xiao S, Li D, Corse JM, et al. Codeletion of p15and p16 genes in primary non-small celllung carcinoma[J]. Cancer Res, 1995,55(12):2968. 叶玉坤.;肺癌发生发展中的分子事件与肺癌的早期诊断[J]
- A homolygous loss was found in SU DHL 9 while mutations of P16 exon 2 in SU DHL 1 and Daudi. 检出1例纯合缺失 ,2例 P16基因第二外显子突变。
- Objective To study the expressions of p16,cyclinD1,CDK4and anal-yse their significances in large intestinal cancer. 目的研究大肠癌组织中多肿瘤抑制蛋白(p16)、细胞周期蛋白(cyclinD1)及细胞周期蛋白依赖激酶(CDK4)的表达及其意义。
- Result 1. No p16 methylation were found in BEP2D cell, p16methylation were found in R-20 , R-30, T-35, T-54 cells. 结果 1正常BEP2D细胞株p16基因未发生甲基化改变，而R-20，R-30，T-35，T-54细胞的p16基因均发生了甲基化改变。
- ObjectiveTo detect the p16 protein and cyc linD 1 in gastric epithelial dysplasia and adenocarcinoma. 目的 检测胃异型增生上皮及胃腺癌组织中p16蛋白和细胞周期蛋白D1(cyclinD1)的表达。
- However, the transcription level of p16 INK4A gene could not be associated with DNMT1 in SW1116 cell. 各组细胞p16 INK4A基因的表达差异不明显。
- Out of the 82 patients, 6 seemed to have deletion of p16 gene, including 1 AML(1.7%) and 5 ALL(20.8%). 82例AL患者中有6例p16基因缺失;缺失率为7.;3%25;在AML、ALL患者中分别为1
- Overexpression of cyc lin D1 and cdk4 were revealed in these samples and p16 was undertectable. p16在卵巢癌中低表达 ,cyclinD1和cdk4过度表达 ;
- P16 messenger RNA (mRNA), p27mRNA weredetected by in situ hybridization (ISH) in these tissues. 应用原位杂交技术检测相应组织中p16mRNA和p27mRNA的表达。
- Methods The expression of p16 protein in 65 cases of ESC was detected by immunohistochenical (S - P) method. 方法应用LSAB免疫组织化学方法检测65例ESC中p16蛋白表达的情况，探讨它与病理组织学分级、临床分期、淋巴结转移和预后的关系。
- Besides, the gene expression of c-myc, wtp53, p16 and EGFR was detected by RNA dot blot. 应用完整细胞原位斑点印迹杂交技术检测c-myc、野生型p53(wtp53)、p16和EGFR的基因表达;
- Methods:The plasmid pcDNA3 containing the wild type p16 gene and neo gene was used in the transfection experiment. 方法：采用pcDNA3质粒进行转染，该质粒含有野生型P16基因片段和新霉素抗性基因。
- There was no significant difference in the density of CDK4 and P16 staining between BCC and KA (P> 0.05). 二者的表达在基底细胞癌与角化棘皮瘤之间无显著性差异(P>0.;05)。
- There were higher expression of Bax,Bcl 2,P16 and P21 in the GAC subjects with higher differentiation ( P <0.05). 高分化胃腺癌中Bcl 2、Bax、P2 1 WAF1、P16 MTS1表达较低分化者高 ;
- There were no remarkable significant in the positive rate of P16 protein between AML and NDA. AML组P~(16)阳性率与营养性贫血组相比;差异无显著性(P>0.;05)。
- There were significantly more CDK4 and less P16 in SCC than in BCC and KA (P< 0.05,P<0.01). 鳞状细胞癌中CDK4表达明显高于基底细胞癌及角化棘皮瘤(P<0.;01;P<0
- Results showed the delation of P16 were high in ALL in 36 cases of leukemia patients. 结果36例白血病中以急性淋巴细胞白血病（ALL）P16缺失表达率最高。
