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- One SNP was identified in kappa opioid receptor gene (GenBank: AY130756). 阿片受体基因在杜洛克猪种中表现较大的变异性,在大白猪种中变异相对较小。
- In the normal brain and the body of some organs, the existence of endogenous opioid peptides and opioid receptor. 在正常人的脑内和体内一些器官,存在着内源性阿片肽和阿片受体。
- Antinociceptive Effect of Morphine, but Not? Opioid Receptor Number, Is Attenuated in the Spinal Cord of Diabetic Rats Chen S-R, et al. 是吗啡的抗伤害作用,而非阿片受体的数目在糖尿病性大鼠的脊髓中降低。
- Till now, Mu opioid receptor's DNA and genomic DNA of human, mouse and pig were cloned in many laboratories in the world. Mu阿片受体cDNA由我国学者于雷最先成功克隆,到目前为止,世界上已有多个试验室克隆到人、鼠和猪的Mu阿片受体的cDNA和基因组DNA。
- Endorphins, a known substances produced in brains is an opioid receptor agonist which the brain produce in the presence of pain stimulus. 如果你一连几天、一天几次进行实验:诱发某人身感疼痛,再用吗啡为他止疼,到最后一天,悄悄用盐水取代吗啡,你会发现,此时盐水也能止痛。
- Conclusion: PPL has a dose-dependent analgesic effect and its analgesic effect might be mediated by central opioid receptor. 结论:灯笼草具有镇痛作用,其镇痛作用可能涉及中枢阿片受体。
- Naloxone is a specific opioid receptor antagonist,which is used on treating a lot of diseases of endogenous opioid peptides. 纳洛酮是阿片受体特异拮抗剂,用于治疗与内源性阿片类物质释放有关的多种疾病。
- Under normal circumstances, the role of endogenous opioid peptides in the opioid receptor, regulating a person's mood and behavior. 在正常情况下,内源性阿片肽作用于阿片受体,调节着人的情绪和行为。
- Our results suggest that the delta opioid receptor can modulate EAAC1function by direct protein-protein interaction and that activation of DOR releases theinhibitory interaction. 与EAAC1功能实验一致的是DPDPE激活DOR会减弱他们之间的相互作用。 我们的结果提示delta阿片受体可以通过蛋白-蛋白间的相互作用来调节EAAC1的功能,而DOR的激活可以释放这种相互作用导致的抑制作用。
- The possibility of the Kappa opioid receptor (KOR) gene as the candidate gene affection the stereotyped behavior traits in sows was discussed in the current study. 摘要 行为规癖是母猪一种常见的异常行为,表现为重复、不变化的行为模式,并且不带有明显的目的性。
- The target receptor of psychoactive substance is opioid receptor and the non-target receptor mainly includes dopamine receptor, NMDA receptor, histamine receptor, and so on. 精神活性物质作用的靶受体为阿片受体,非靶受体主要包括多巴胺受体、N-甲基-D-门冬氨酸(NMDA)受体和组胺等。
- Actions of NO/NOS system are involved in the activation of opioid receptors. NO/NOS系统作用与阿片受体的激活相关;
- In comparable doses, dynorphin A2-17, which is inactive at the opioid receptor,produced similar alterations in EAA as dynorphin A1-17, whereas dynorphin A1- 8 caused significantly smaller changes. 相同剂量的非阿片受体激动剂DynA2-17和阿片受体激动剂DynA1-17对脊髓EAA的改变相似,DnyA1-8也产生显著的EAA改变,但程度较小。
- Contractive responses of arterial strips evoked by electric field stimulation were distinctly enhanced after treatment of arte- rial strip with naloxonc, an opioid receptor blocker, and pronase, but unchanged after treatment with trypsin. 动脉条用阿片受体阻断剂纳洛酮或链霉蛋白酶处理后,电场刺激引起的动脉条收缩反应显著增大,但胰蛋白酶无影响。
- Previous studies were conducted to investigate opioid receptor in brain and endogenous opioid peptides (EOP), but recent investigations had shown the changes of opioid receptor in brain and EOP couldn't explain the mechanisms of drug dependence. 以往对阿片依赖的研究主要集中在脑内阿片受体及内源性阿片肽上,但经研究发现单纯用阿片受体和阿片肽的变化不足以解释阿片类依赖和耐受,因此人们将研究重点转移到受体后机制。
- Regulation of opioid receptor activities does not appear to involve in their ability to promote the association of GTP onto the G proteins and the subsequent dissociation of heterotrimers. 阿片受体活性的调节可能并没有涉及到它们将GTP和G蛋白相联系的能力,以及相继的异源三聚体的解离能力。
- Dr.Bello and colleagues report that either continuous eating or binge eating a high fat, high sugar diet alters opioid receptor levels in an area of the brain that controls food intake. 贝洛克博士和他的同事们在报告中提到,无论是不停吃东西还是大量食用高脂肪食物,高糖饮食都会在控制食物摄入的大脑区域内改变阿片类受体量。
- She predicts that methadone will have similar effects in other cancers that express opioid receptors. 她预言美沙酮在表达阿片受体的其他肿瘤也会有类似的作用。
- Like opioid receptors, N-type calcium channels occur throughout the nervous system. 一如鸦片类受体,N型钙离子通道也分布在整个神经系统。
- The results suggest that Y1 receptor may mediateNPY-induced anti-nociception, and that the opioid receptors in PAG may also be involved in this process in mononeuropathic rats. NPY引起的PWLs增加可被Y1受体拮抗剂和阿片剂所阻断.;结果提示;在大鼠PAG 微量注射NPY可产生明显的镇痛作用