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- OBJECTIVE To study the effect of ionic strength on insoluble drug release from HPMC hydrogel matrix. 目的:探讨溶出介质的离子强度对难溶性药物的丙基甲基纤维素(HPMC)骨架片释药的影响。
- RESULTS Ionic strength could affect the insoluble drug release from the HPMC hydrogel matrix. 结果:难溶性药物的HPMC骨架片释药随着其溶出介质离子强度的增加而减慢。
- Keywords 5-amino salicylic acid;calcium pectinate;pellets;Ca content;extrusion-spheronization;insoluble drug release;enzyme-decomposed; 氨基水杨酸;果胶钙;微丸;钙含量;成球性;药物释放;酶降解;
- insoluble drug release 药物释放
- OBJECTIVE The effect of different diluents on the release rate of insoluble drug from HPMC hydrogel matrix was investigated. 目的探讨稀释剂对难溶性药物的HPMC骨架片释药的影响。
- SR on the drug release was great, variations of Kollidon? SR用量对药物释放影响较大;
- The mechanism of drug release from swellable polymer was studied . 对药物从亲水聚合物凝胶系统中释放的机理进行了研究。
- The paddle method was used to study the drug release properties of RFP-PLA-MS. 考察了微球在不同温度下的稳定性;
- Conclusion The validated mathematical model can be used to explain and predict the combined solubilization of the two insoluble drugs in different cosolvent systems. 结论该数学模型可以用于解释和预测潜溶剂和环糊精对难溶性药物的联合增溶作用。
- Objective To prepare Emedastine Difumarate Sustained-release Tablets(EDST),and develop a method for the determination of drug release rate. 目的制备富马酸依美斯汀缓释片,并建立其释放度测定方法。
- The study examine the drug release mechanism of famotidine chitosan microcapsule. 初步研究了法莫替丁-甲壳胺微囊的释药机理。
- Accelerated release testing could be applied to evaluate the drug release profile of huperzineA PLGA microspheres. 加速释放度试验可用于快速评价石杉碱甲微球的释药特性。
- The alidated mathematical model can be used to predict small-molecule drug release from PLG microsphere population. 对于多元分散体(分散参数<3)结合微球大小的数学模型比只用平均粒径更与试验结果相符。
- Objective To prepare estradiol sustained-release capsules for vagina and evaluate the drug release property. 摘要目的制备雌二醇阴道用缓释胶囊,并考察其体外释药行为。
- The absorbency of the drug in PBS was detected and the velocity of drug release was counted by UV-visible spectroscopy. 通过紫外分光光度计检测其释放在磷酸缓冲溶液(PBS)中药物的吸光度,并计算其释药速率。
- OBJECTIVE To prepare sustained-release Palmatine tablets and evaluate its drug release property. 目的:确定黄藤素缓释片的制备工艺,并进行其释放特性的研究。
- Objective To prepare colchicine sustained-release pellets and investigate the drug release mechanism in vitro. 目的 制备秋水仙碱缓释微丸,并对其体外释药规律进行考察。
- Objective: To prepare nefopam hydrochloride sustained-release tablets and investigate the drug release in vitro. 目的:研制盐酸奈福泮缓释片,并考察其体外释放度。
- Objective To prepare paracetamol sustained-release pellets and investigate the drug release mechanism in vitro. 目的制备扑热息痛缓释微丸,并对其体外释药情况进行研究。
- Oil is insoluble in water under common conditions. 油在常规条件下是不能溶解于水的。