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- No evidence of drug accumulation with prolonged therapy has been noted. Therapeutic effects have been observed from 2 to 8 months after initiation of therapy. 延长治疗时间未产生明显的药物累积效应。治疗2-8个月后即可观察到治疗效果。
- Verapamil increased the intracellular drug accumulation, and then obviously reversed the drug resistance to DNR, VCR, MIT, HHT, and VP 16 in K562/D cells, but not in the sensitive cells (K562/S). 异搏定使 K 5 6 2 / D细胞内药物积聚增加 ,明显地逆转了 K5 6 2 / D细胞对 DNR、VCR、MIT、HHT、VP- 16的耐药性 ,而对敏感细胞 K5 6 2 / S的耐药性无影响。
- The fluorescence intensity in SGC7901/Adr cells was much lower,indi- cating that the decrease of drug accumulation in SGC7901/Adr cells might contribute to the devel- opment of the multidrug resistance of SGC7901/Adr. 应用流式细胞术检测细胞阿霉素荧光强度,发现 SCG7901/Adr 细胞内阿霉素浓度明显低于 SGC7901,提示细胞内药物蓄积减少是导致SGC7901/Adr 产生多药耐药性的主要原因。
- Methods:The effects of cyclosporin A (CsA) on drug sensitivity,intracellular drug accumulation and drug efflux in multidrug resistant human leukemic cell line K562/DOX were studied by MTT colorimetric assay and spectrofluorimetry. 方法：以环孢霉素A（CsA）作为耐药逆转剂，用MTT法体外药物敏感试验，观察CsA对多药耐药白血病细胞株K562/DOX的药物敏感性、细胞内药物的积聚和外排的影响。
- Keywords Wild Aconite;Drug Accumulation;Drug Pharmacokinetics; 草乌;药物累积法;毒代动力学;
- The nurse diluted the drug with saline water. 护士用生理盐水把药加以稀释。
- An accumulation of data to be processed. 要处理的数据的一种聚集。
- An accumulation of work is waiting to be done. 一堆积下的工作等著要做。
- We are testing the efficacy of a new drug. 我们正在测试新药的功效。
- I am surprised to learn that he is taking drug. 听说他在吸毒，我很吃惊。
- His business was a cover for drug dealing. 他的商行是进行毒品交易的幌子。
- Use of this drug is now fairly generalized. 这种药现在用得相当普遍。
- Some drugs accumulate, producing higher concentratio in cells than in ECF, most commonly because they bind with protein, pho holipids, or nucleic acids. 某些药物在细胞内积聚，使细胞内浓度高于细胞外液浓度，最常见的原因是他们与蛋白质、磷脂或核酸的结合。
- He was convicted of drug offences and deported. 他被判犯有毒品罪而遭驱逐出境。
- Some drugs accumulate, producing higher concentrations in cells than in ECF, most commonly because they bind with protein, phospholipids, or nucleic acids. 药物储库 药物在组织或机体腔室的积聚能延长药物在血浆中的逗留时间，从而延长药物作用时间，这是因为，当血浆药物浓度下降时，组织就会把贮存药物释放出来。
- She pioneered the use of the drug. 是她最先使用的这种药品。
- The new drug has performed well in tests. 那种新药试验效果不错。
- An accumulation, especially of unfinished work or unfilled orders. 积压堆积物，尤指没完成的工作或未兑现的定单
- A drug, especially an illicit or addictive one. 麻醉剂尤指非法使用或使人上瘾的麻醉剂
- This new drug is not yet commercially available. 这种新药还没有投放市场。
