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- In this experiment, DNA double strand breaks induced by heavy ions in the early period were investigated with atomic force microscopy (AFM). 本实验旨在用原子力显微镜(AFM)研究重离子辐射后早期的DNA双链断裂。
- HR can repair the DNA double strand breaks (DSBs) which is the most severe damage of DNA. It is not known whether Hp induce the occurrence of GCa by inhibiting the functions of BER genes and HR genes? HR是真核细胞修复DNA双链断裂(DNA double strand breaks, DSBs)的一个重要途径, HR相关基因的缺陷可引起DSBs修复减少,肿瘤发生率显著增加。
- Pulsed field gel electrophoresis has been applied to compare the sensitivity of B16 cells and their DNA molecules in the induction of DNA double strand breaks (DSB) by 50 MeV/u 12 C 6+ beam. 用倒转脉冲场凝胶电泳 (PIGE)比较研究了 50 Me V/u1 2 C6 +辐照小鼠 B1 6黑色素瘤细胞及其脱蛋白 DNA分子 ,从而诱导 DNA双链断裂 (DSB)的辐射敏感性。
- The NBS1 is a component of the MRE11/RAD50/NBS1 complex (MRN) and plays a critical role in the DNA double strand break (DSB) repair and the maintenance of chromosomal integrity. NBS1作为MRE11/RAD50/NBS1复合物的组分之一,是细胞应答DNA损伤的一个关键蛋白质,在DNA双链断裂修复和维持基因组稳定中发挥重要的作用。
- Radiosensitization effect of 3-aminobenzamide( 3-AB), a specific inhibitor of ADP-ribose transferase( ADPRT), on cell colony formation and DNA double strand break (DSB), repair of human tumor cells was studied. 目的：从细胞的克隆形成能力和细胞DNA双链断裂及修复几方面探讨了ADP－核糖基转移酶（ADPRT）的特异性抑制剂3－氨基苯甲酰胺（3－AB）对人卵巢癌细胞株HOC8的放射增敏效应。 结果表明，3－AB能降低受照细胞的克隆形成能力；
- Using plasmid pGEM-3Zf(-) and M13mpl8 RF DNA, this thesis studied the DNA damage (DNA single strand break (SSB) and double strand break (DSB)), and gene mutation spectra induced by 30keV N+, C+ ions. 本文以质粒、噬菌体为实验材料，主要研究30keV的N~+、C~+引起的DNA分子损伤(单双链断裂)和它诱发基因突变的特点和规律。
- Objective To construct DNA double strand break(DSB) repair protein hKu70 deficient cell strain and to observe its biological characters for studying the functions of hKu 70 gene and the effects of occupational harmfulness factors on DSB repair. 目的 建立并鉴定DNA双链断裂 (DSB)修复蛋白hKu70缺陷细胞株 ,并观察该缺陷细胞的某些生物学效应 ,用于hKu70基因功能及职业有害因素对DNA双链断裂修复影响的研究。
- Relationship between the Constitutes of DNA Double Strand Breaks and Scavenging Capacity DNA双链断裂的组成与自由基清除效能的关系
- Measurement of DNA Double Strand Breaks in Mammalian Cells After Ionizing Radiation by Pulsed Field Gel Electrophoresis 用脉冲电场凝胶电泳检测电离辐射所致哺乳动物细胞DNA双链断裂
- Keywords DNA double strand breaks;non-homologous end joining;DNA-dependent protein kinase;telomere;viral integration; DNA双链断裂;非同源末端连接;DNA依赖蛋白激酶;端粒;病毒整合;
- deoxyribonucleic acid double strands break 双链脱氧核糖核酸断裂
- DNA double strand break and repair of human tumor cells irradiated by high LET heavy ions 高LET重离子照射人肿瘤细胞的DNA双链断裂及修复研究
- THE EFFICIENCY AND FIDELITY OF REJOINING OF THE DNA DOUBLE STRAND BREAK IN THE IMMUNOCYTES OF TONSILS OF IRRADIATED MICE 小鼠扁桃体免疫细胞受照射后DNA双链断裂损伤修复的忠实性
- DNA double strand breaks (DSBs) 双链DNA断裂
- DNA double strand breaks repair DNA双链损伤修复
- It has linear double strand DNA,icosahedral-capsid and envelope. 其核酸结构为线状双股DNA,衣壳为二十面体对称,有囊膜。
- DNA double strand breaks DNA双链断裂
- double strand breaks(DSBs) DNA双链断裂（DSBs）
- Immunohistochemical double staining showed that BrdU positive cells could costain with TUNEL, a marker of double strand DNA breaks, and 8-oxoG, an oxidative damage marker. 这提示BrdU+TUNEL双标细胞并不是新生神经元，这反应了缺血早期的BrdU掺入主要标记体内DNA的修复，且Bcl-2在缺血脑组织中的过表达可以影响体内的DNA修复能力。
- The ability of trichloroethylene(TCE) to induce single strand breaks in peripheral lymphocytes DNA of male mice in vivo was evaluated using single cell gel electrophoresis(SCGE). 为研究三氯乙烯（TCE）的遗传毒性，应用单细胞凝胶电泳法（SCGE）测定了TCE诱导人和小鼠外周血有核细胞DNA链断裂的能力。
