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- Objective To study the apoptosis effects and the mechanisms of action by homocysteine on dopaminergic neurons. 目的:研究同型半胱氨酸能否通过内质网应激的途径诱导多巴胺能神经元凋亡。
- Abstract： Objective To study the toxicity of exogenous dopamine(DA) in dopaminergic neurons. 摘 要： 目的研究外源性多巴胺对多巴胺能神经元的毒性作用。
- In many parkinson's cases, the damage can be seen in autopsies as clumps of proteins within the substantia nigra's dopaminergic neurons. 解剖许多帕金森氏症患者的尸体后发现，黑质多巴胺神经元中有堆积成块的蛋白质。
- The medial forebrain bundle of rats was transected with a wire knife to set up a model of chronic degeneration of dopaminergic neurons. 采用线刀切断大鼠内侧前脑束造成多巴胺能神经元的慢性退行性改变。
- The effects of BDNF、SDNF、GM1 on growth and development of embryonic ventral mesencephalic (VM) dopaminergic neurons were studied in vitro. 本研究在体外培养的条件下研究了BDNF、SDNF、GM1对大鼠胚腹侧中脑多巴胺神经元生长发育的影响。
- Parkinson's disease is a neurodegenerative disorder which is caused by the death of dopaminergic neurons in the compact part of nigra. 摘要帕金森病是黑质多巴胺能神经元变性坏死而引起的神经系统退行性疾病。
- The GDNF protein expressed in Pichia and silkwom larvae could significantly promote the survival and neurite outgrowth of dopaminergic neurons. 活性研究表明，甲醇酵母及家蚕幼虫表达的GDNF蛋白能促进多巴胺能神经元的存活和突起生长。
- Objective:To explore the optimal condition on which embryonic stem cell may be induced to differentiate directly into dopaminergic neurons. 目的:探讨由胚胎干细胞向多巴胺能神经元方向分化的最佳诱导条件。
- Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigra. 帕金森氏病（PD）是一种神经退行性疾病，其特征为黑质的多巴胺能神经元变性。
- It remains unclear whether this is related to motor symptoms or represents adaptive compensatory changes to degeneration of dopaminergic neurons. 但是，这种现象是否与运动症状相关，或者是一种针对多巴胺能神经元变性的适应性代偿改变。
- At present,pharmaceutical therapy has various shortcomings,while the replacement therapy of dopaminergic neurons shows competitive prospect. 尽管目前存在药物治疗的缺陷,但是多巴胺能神经元的替代治疗呈现出广阔的前景。
- Using a rat model of Parkinson's disease, the researchers show that CDNF treatment can preent the degeneration of dopaminergic neurons. 利用一种大鼠帕金森氏病的动物模型，研究者发现使用保守型神经营养因子进行治疗可以有效的防止多巴胺能神经元发生退行性病变。
- One injection of the factor into the striatum, prior to injection of the damage-inciting agent 6-OHDA, almost completely rescued dopaminergic neurons in the substantia nigra. 在注射致损伤药物6-羟基多巴胺之后，只需要向纹状体中注入一次保守型神经营养因子，就可以使黑质中的多巴胺能神经元几乎完全得以复苏。
- Objective To investigate the neuroprotective effect of repetitive preconditioning with 3-nitropropionic acid (3-NPA) on dopaminergic neurons and the role of N-myc in it. 目的 研究 3 硝基丙酸 (3 NPA)多次预处理对多巴胺能神经元的保护及即早基因N myc在其中的作用。
- Parkinson's disease arises from genetic and possibly neurotoxic causes that produce massive cell death of the neuromelanin-containing dopaminergic neurons of the substantia nigra. 帕金森氏病的病因包括基因突变和神经毒性物质作用，导致黑质多巴胺能神经元大量的死亡。
- After labeled by tyrosine hydroxylase, the differentiated dopaminergic neuron proportion was detected by a flow cytometer. 酪氨酸羟化酶染色标记后通过流式细胞仪检测分化的多巴胺能神经元比率。
- Parkinson s disease(PD),is a progressively neurodegenerative disorder,resulting from the degeneration and loss of dopaminergic neurons in the substantia nigra of midbrain. 帕金森病是一种以中脑黑质多巴胺能神经元变性缺失为主要病理变化的渐进性神经系统退行性疾病。
- Objective To investigate the function of amnion endothelial cell in the differentiation of human umbilical cord blood stem cells into dopaminergic neurons. 摘要 目的 探讨羊膜上皮细胞对人脐血干细胞定向分化为多巴胺能神经元的作用。
- Pathological changes of Parkinson's disease occur mainly in substantia nigra and corpus striatum and infringe only upon one kind of dopaminergic neurons. 帕金森病的病理改变主要在黑质、纹状体,最大特点是病变只侵犯单一类型的多巴胺能神经元。
- OBJECTIVE: To explore the differentiation of NSCs which were incubated in differentiation solution for different time towards dopaminergic neurons in vitro. 目的：探讨大鼠神经干细胞在分化液中诱导不同时间后，其体外分化成多巴胺能神经元的效应。
