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- Chiral drugs are more important in new drugs. 手性药物在新药中越来越受重视。
- Now, the most important thing is to obtain one of the chiral drug enantiomers. 因此,获得单一对映体的药物成为一项重要的工作。
- The enantiomer of some chiral drugs has different pharmacology activity and different applying. 手性药物对映体具有不同的药理活性和不同的用途。
- In this review the stereoselective pharmacodynamics of calciumchannel blockers and chiral drugs are summarized. 本文就以手性药物和钙通道阻滞剂的药效学立体选择性作一综述。
- Resolution of racemic drugs by lipase catalysis offers an excellent technology for the preparation of single-isomer chiral drugs in organic solvent. 在有机相中,脂肪酶催化消旋体的拆分,为制备单异构体手性药物提供了重要的技术手段。
- The resolution of some chiral drugs such as D,L-dansyl amino acid has certain rule, and provides information about absolute configuration. 对一些物质,如D,L-丹酰化氨基酸的拆分有一定的规律,能给出绝对构型信息。
- Pharmacological interactions between the enantiomers may happen when a chiral drug was used as its racemate. 当手性药物以外消旋体供药用时,其对映体间就可能发生药效学和药代动力学的相互作用。
- This article reviews the present applications of cyclodextrins in chiral drug resolution. 介绍了环糊精在手性药物拆分中的应用情况。
- The selection of developing chiral drugs as strategy is on the important basis of chiral pharmacology study results but it is necessar... 选择手性药物开发战略的重要依据是手性药理学研究结果,同时还应综合考虑科学和经济学标准。
- The selection of developing chiral drugs as strategy is on the important basis of chiral pharmacology study results but it is necessar. 基础生物化学研究推动手性药物市场持续增长,2001年单一对映体药物市场为1470亿美元,占世界药品市场4100亿美元的36%25。
- Aim:To study the feasibility and influential factors for the resolution of HPLC-DAD data of chiral drugs by non-negative matrix factorization(NMF) algorithm. 目的:研究非负矩阵因子分解算法(NMF)用于手性药物HPLC-DAD二维数据解析的可行性及其影响因素。
- The research progress on applications of MIP in chiral drug separation and clinical drug analysis in the recent years was expounded. 综述了近年来分子印迹聚合物在手性药物分离和临床药物分析应用方面的研究进展。
- The determination of absolute configuration for chiral compounds is one of the most important problem in the organic chemisty, especially for chiral drug synthesis. 手性化合物绝对构型的确定一直是有机化学特别是手性药物合成研究过程中经常遇到的问题之一。
- Quebrachitol, isolated from Hevea brasiliensis latex, can be simply used as a starting material to synthesize chiral drugs with special effect for the treatment of cancer, early ageing, diabetes and AIDS in pharmaceutical drug manufactures. 利用巴西橡胶胶乳提取具有旋光性的天然产物白坚木皮醇为植物药物原料,可供制药工业简单而方便地合成无毒、害而有特效的手性药物,用于治疗癌症、老期痴呆症、尿病和艾滋病等疾病。
- This paper summarizes recent advances in chromatographic separation of chiral drugs,and introduces separating mechanisms,determining methods, reagents and applications of CDR, CMPA and CSP. 综述了近年来手性药物色谱分离的研究进展。对手性衍生化试剂法、手性流动相添加剂法和手性固定相法的分离机理、检测方法、试剂种类和应用等作了介绍。
- The application of microbial transformation in the synthesis of pharmaceuticals, especially the recent advances in asymmetric synthesis of chiral drugs and biocatalytic methods, is reviewed. 概述了微生物转化在药物合成中的应用,特别是在手性药物的不对称合成和生物催化方法方面的新进展。
- OBJECTIVE:In this paper, the principle, feature and its application to the protein binding study of chiral drugs by High performance capillary electrophoresis /frontal analysis (HPCE/FA) are reviewed. 目的:综述了高效毛细管电泳/前沿分析(HPCE/FA)方法的原理、特点、及其在手性药物-蛋白结合研究中的应用。
- This paper summarizes recent advances in chromatographic separation of chiral drugs,and introduces separating mechanisms,determining methods,reagents and applications of CDR,CMPA and CSP. 综述了近年来手性药物色谱分离的研究进展。对手性衍生化试剂法、手性流动相添加剂法和手性固定相法的分离机理、检测方法、试剂种类和应用等作了介绍。
- In addition, the company left chiral drugs market space Leucovorin wide by the Japanese director of the Central Committee for Drug for the treatment of renal cell carcinoma and colon cancer. 此外,公司生产的手性药物左亚叶酸钙市场空间广,被日本中央药物理事委员会推荐用于治疗肾癌和结肠癌。
- The enantiomers of a chiral drug may have different properties in absorption, distribution, metabolism and/or elimination.This phenomenon is regarded as the stereoselectivity in pharmacokinetics. 药代动力学立体选择性是指手性药物对映体在吸收、分布、代谢和消除过程中有差异。