您要查找的是不是：
- Apoptosis of drug-resistant human ovarian cancer cell line COC_1/DDP induced by survivin antisense oligonucleotides. Survivin反义寡核苷酸诱导人卵巢癌耐药细胞株COC_1/DDP凋亡的实验研究
- Objective To study antiviral effect of Lihposome-mediated antisense oligonucleotides COS-ASIN. 目的 研究脂质体介导的反义寡核苷酸在体外对乙型肝炎病毒基因复制和表达的抑制。
- Antisense oligonucleotides have been successfully employed to inhibit and modulate specifically gene expression. 反义寡聚核苷酸已成功用于对基因表达的特异性调控与抑制。
- Objective To study inhibition of VEGF expression in human bladder carcinoma cells by antisense oligonucleotides. 目的观察VEGF反义寡核苷酸对膀胱癌细胞VEGF表达的抑制情况。
- "As compared to conventional drugs that work on proteins, antisense oligonucleotides work on RNA. 与传统的作用于蛋白质的药物相比，反义寡聚核苷酸作用于RNA。
- Until now,several methods have been developed to improve the intracellular delivery of antisense oligonucleotides. 到目前为止,已发展了数种提高寡聚核苷酸类化合物细胞内转运的方法。
- Including antisense oligonucleotides, ribozymes, at the wrong virus interferents, such as cell suicide gene. 包括反义核苷酸、核酶、缺陷病毒的干扰剂、细胞自杀基因等。
- Survivin antisense oligonucleotides could effectively induce apoptosis of drug-resistant human ovarian cancer cell line COC1/DDP. survivin ASONs反义寡核苷酸能诱导人卵巢癌耐药细胞株COC1/DDP细胞凋亡 ,且效果显著
- HSP 70 antisense oligonucleotides could not only inhibit the proliferation,but also induce the apoptosis of Eca-109 cells. HSP70反义寡核苷酸能抑制Eca-109细胞的生长并诱导其发生凋亡。
- Dai MS, Luo SK, Dai LJ, et al.Inducing apoptosis ofK562 cell lines by bcr-abl antisense oligonucleotides [J].Chin J Hematol, 1997, 5(5): 264-5. [6]戴木水;罗绍凯;戴丽君;等.;反义bcr-abl寡核苷酸诱导K562细胞凋亡的研究[J]
- The aim of gene therapy is to transfect DNA into target cells, in which ultilizing antisense oligonucleotides is a main method. 基因治疗是将DNA转染进入目的细胞,修复遗传错误或产生治疗因子。反义寡核苷酸的应用是基因治疗的主要手段之一。
- Results VEGF antisense oligonucleotides obviously inhibited VEGF expression in human bladder carcinoma cells and proliferation of endothelial cells. 结果VEGF反义寡核苷酸对膀胱癌细胞的VEGF表达有明显的抑制作用。
- The recent progress in chemical modifications of antisense oligonucleotides including modifications of backbone, sugar-ring and base is reviewed. 本文就近几年来反义寡核苷酸在化学修饰方面,包括骨架修饰、糖环修饰、碱基修饰等的最新发展进行了综述。
- In this paper,the use of synthetic polymer and special methods to improve the delivery of antisense oligonucleotides were discussed. 现对提高寡聚核苷酸细胞内转运的载体和方法作一较详尽的归纳。
- The present study has attempted to address the above unresolved issues using antisense oligonucleotides directed against the c-myc proto-oncogene. 探讨c-myc反义寡核苷酸局部给药防治再狭窄的机制，了解c-myc反义寡核苷酸在细胞和分子水平的作用机制。
- Antisense oligonucleotides have been broadly applied in specific inhibition of gene expression in many organs, including liver. 反义寡核苷酸技术已被广泛用于在许多组织中抑制特定基因的表达。
- Intrathecal injection of eNOS antisense oligonucleotides inhibited the expression of NMDA1AR mRNA in the spinal cord of morphine-withdrawal rats, but did not in the brainstem. eNOS反义寡核苷酸也可抑制吗啡戒断大鼠脊髓NMDA1AR mRNA表达的增加, 但作用弱于nNOS反义寡核苷酸, 对脑干NMDA1AR mRNA表达无明显影响。
- Objective To investigate the effect of HSP 70 in the proliferation and apoptosis of esophageal cancer cell line Eca-109 by inhibiting HSP 70 expression with HSP 70 antisense oligonucleotides. 目的观察热休克蛋白70(HSP70)反义寡核苷酸阻断食管癌Eca-109细胞的HSP70表达及对细胞增殖和凋亡的影响。
- This process seems to be modulated by CRF receptor 1. Evidences taken from CRF receptor 1 transgenic knockout mice, CRF receptor 1 antisense oligonucleotides work, as well as receptor 1 selective antagonist studies all suggested this conclusion. 研究表明;应激、焦虑与促肾上腺皮质激素释放因子(CRF)及其受体有关.
- After transfection with HSP 70 antisense oligonucleotides,the expression of HSP 70 was partially blocked,the proliferation of Eca-109 cells was apparently inhibited,and its inhibitory rate was increased to 25.5% at 48h and 35.4% at 72h respectively. HSP70反义寡核苷酸可阻断Eca-109细胞HSP70mRNA和蛋白的表达; 转染后48h和72h;生长抑制率分别为25.;5%25和35
