Antisense oligonucleotides have been broadly applied in specific inhibition of gene expression in many organs, including liver. 反义寡核苷酸技术已被广泛用于在许多组织中抑制特定基因的表达。
Cantide and Flutide are 20-mer and 13-mer antisense phosphorothioate oligonucleotides, which showed significant antitumor activities and antivirus activites in vitro and in vivo. 癌泰得和流感泰得为本室筛选出的两种具有较好抗肿瘤及抗病毒活性的硫代反义寡核苷酸化合物。