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- The binding of antigenic peptide sequences to major histocompatibility complex(MHC) molecules is a prerequisite for stimulation of cytotoxic T cell responses. 抗原多肽序列与主要组织相容性复合体(MHC)分子的结合是引起T细胞免疫应答的先决条件。
- Recent researches have demonstrated that the ATPase domain of HSP70 and the tumor antigenic peptide that binds to Hsp70 were the crucial parts eliciting tumor-specific immunity. 最近的研究表明HSP70携带的小肽及其ATPase结构域是HSP70抽提物激活肿瘤特异性免疫反应的关键。
- Somatostatin receptor-like immunoreactivity was in most cases located at the plasma membrane as well as in the cytoplasm of the tumor cells and was completely blocked with antigenic peptide. 良性卵巢上皮肿瘤组织中大部分细胞的胞浆和胞膜都呈强染色,呈棕褐色。
- Branched multiple antigenic peptide 分支多抗原肽
- Aβ1-15 multiple antigen peptide vaccine Aβ1-15多重抗原肽疫苗
- human soluble antigen peptide 35(HS-Ag P35) 人视网膜可溶性抗原第35段抗原决定簇
- Conclusion The phage display technique can be applied to study the viral antigenic peptides with the advantages of simple, accuracy and rapidity. 结论噬菌体展示技术完全可应用于病毒蛋白抗原序列的筛选,并具有简便、快速、准确的优点。
- Design of the antigenic peptide of human doc-1 protein 人doc-1蛋白抗原肽的设计
- Methods The tumor antigen peptides from 4T1 breast cancer cells were acquired by freeze thawing method and HSP70-4T1 peptides complex was reconstructed in vitro. 方法冻融法获取BALB/C小鼠4T1乳腺癌细胞抗原肽,体外重组HSP70-4T1抗原肽复合物。
- The transporter associated with antigen processing(TAP) plays a pivotal role in the presentation of intracellular antigen by translocating intracellular antigenic peptides from the cytosol into the lumen of endoplasmic reticulum(ER). 抗原处理相关转运体蛋白(transporter associated with antigen processing,TAP)在内源性抗原提呈过程中有重要作用,负责内源性抗原从胞浆到内质网(ER)腔的转运。
- The immune system attacks foreign cells - be they tumor cells, virally infected, or donated by another person - when T lymphocytes recognize antigenic peptides displayed on the cell surface. 当T淋巴细胞识别出细胞表面存在抗原多肽时,免疫系统便将其认为异种细胞,并开始攻击,这些异种细胞包括肿瘤细胞,病毒感染的细胞和来源于捐赠人的细胞。
- The immune system attacks 'foreign' cells - be they tumor cells, virally infected, or donated by another person - when T lymphocytes recognize antigenic peptides displayed on the cell surface. 科学家的惯性思维是,当T淋巴细胞识别“非常态”细胞(肿瘤细胞、病毒感染细胞或者同种异体捐助的细胞)表面提呈的抗原肽时,免疫系统攻击“非常态”细胞。
- Methods Tumor antigen peptides from elemene-combo Hca-F cell (HTA) combined with HSP70BCG into HTA-HSP70BCG in vitro. DCs were induced in medium with GM-CSF and IL-4 and pulsed with HTA-HSP70BCG, HTA and HSP70BCG, respectively. 方法来源于小鼠的肝癌Hca-F榄香烯复合疫苗的抗原(HTA)与卡介苗来源的HSP70(HSP70BCG)在体外构建成HTA-HSP70BCG复合物,用GM-CSF和IL-4诱导树突状细胞(DCs),分别用HTA-HSP70BCG、HTA和HSP70BCG对其冲激。
- The antigenic peptides derived from CT antigens such as MAGE-1[7], MAGE-3[8] and NY-ESO-1[9] have been proven to be elicit CTL responses in the context of MHC class I molecules. 因此,CT抗原无疑是肿瘤免疫治疗的理想靶标。 迄今为止,实验已经证实,来源于多种CT抗原(如MAGE-1,MAGE-3、NY-ESO-1)的抗原肽能够在体外有效地激发特异性的CTL反应。
- Immature DCs uptake, process antigens and present antigen peptides to MHC. Only in this way, can Ags be recognized by TCR on T cells. 未成熟DCs能摄取抗原并将其处理成免疫原性多肽,以MHC分子-抗原肽复合物的形式表达于细胞表面,供抗原特异性T细胞受体(TCR)识别。
- transporter of antigen peptide, transporter associated with antigen processing 抗原肽转运体
- multiple antigenic peptides (MAPs) 多聚抗原肽
- The attraction between an antigen and an antibody. 化合力抗原和抗体之间的相互吸引
- transporter of antigenic peptides 抗原肽转运蛋白
- Peptide 7 had been a notable exception. 缩氨酸7号只是一个引人注目的例外。