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- JOHN A.T.YOUNG and R.JOHN COLLIER have collaborated for several years on investigating the anthrax toxin. 杨恩与柯里尔多年来合作研究炭疽毒素。
- We have not yet learned the normal function of the receptor, which surely did not evolve specifically to allow the anthrax toxin into cells. 我们还不知道这个受体的正常功能,但可以肯定的是,它绝不会是专门演化来引导炭疽毒素进入细胞的。
- These encouraging mouse results suggest that modified anthrax toxin could be clinically viable, and this potent killer might someday be put to good use. 这项令人鼓舞的小鼠实验结果表明,修饰过的炭疽毒素有可能用于临床,也许某天这种有效的杀灭手段会得到良好应用。
- CERTAINLY DRUGS able to neutralize the anthrax toxin would help the immune system fight bacterial multiplication and would probably reduce a patient's risk of dying. 能中和炭疽毒素的药物,当然可以帮助免疫系统对抗细菌的繁殖,可能还会降低患者的死亡率。
- The anthrax toxin, which also enters other cells, is thought to contribute to mortal illness not only by dampening immune responses but also by playing a direct role. 炭疽毒素还会进入人体中的其他细胞。一般相信,它之所以会引起致命的疾病,不只因为降低了免疫反应,还有更直接的作用。
- Objective:To find protective antigen(PA) defective mutants of anthrax toxin with the same function as PA but with low immunogenicity,different domains of PA were mutated. 目的:对炭疽毒素保护性抗原(PA)的不同结构域进行了缺失突变,以期找到免疫原性降低而功能变化不大的PA蛋白突变体。
- Those molecules retain their ability to elicit immune responses.Hence, they could do double duty: disarming the anthrax toxin in the short run while building up immunity that will persist later on. 这些分子保有刺激免疫反应的能力,因此具有双重功能:短期内阻止炭疽毒素,而它所刺激的免疫反应则还会持续下去。
- Progress on the Anthrax Toxin and Its Receptor 炭疽毒素及其细胞受体的研究进展
- Model of Action of the MMP-activated Anthrax Toxin MMP-激活炭疽毒素作用示意图
- PROGRESS ON THE ANTHRAX TOXIN AND THE CELLULAR CLONE RECEPTOR FOR ANTHRAX TOXIN 炭疽毒素及其克隆受体的研究进展
- Keywords anthrax toxin;protective antigen;fusion expression;purification;furin; 炭疽毒素;保护性抗原;融合表达;纯化;弗林蛋白酶;
- For example, they can produce anthrax and botulinum toxin. 例如,它们可以生产炭菌病毒和肉毒菌毒素。
- For example,they can produce anthrax and botulinum toxin. 例如,它们可以生产炭菌病毒和肉毒菌毒素。
- The cake on analysis was found to contain traces of toxin. 经分析发现蛋糕里含有微量的毒素。
- A toxin that damages or destroys nerve tissue. 神经毒素损害或破坏神经组织的毒素
- Construction of shuttle vector of anthrax toxin protective antigen with upstream strong promoter 芽孢杆菌外毒素保护性抗原与上游强启动子穿梭载体的构建
- Progress in research on anthrax toxin receptors and mechanism of their binding to protective antigen 炭疽毒素受体及其与保护性抗原结合机制的研究进展
- Expression, Purification and Characterization of The Recombinant Excellular Portion of Anthrax Toxin Receptor 炭疽毒素受体胞外区在毕赤酵母中分泌表达、纯化与活性鉴定
- Chemical Synthesis and Cloning of cDNA of Anthrax Toxin Receptor (ATR)and Construction of Eukaryotic Expression Vector for ATR-Fc Fusion Protein 炭疽毒素受体ATRcDNA的合成和克隆及ATR-Fc融合蛋白的真核表达载体的构建
- Keywords Anthrax toxin;Protective antigen;Edema factor;Lethal factor;Receptor;Neutralizing monoclonal antibody;Inhibitor; 炭疽毒素;保护性抗原;致死因子;水肿因子;受体;中和性单抗;抑制剂;