When the product accumulates beyond an optimal amount it binds to a site (ALLOSTERIC SITE) on the enzyme, changing the shape so that it can no longer react with its substrate.

• 当产物积累超出最佳数量时，它将与酶的一个氨酰基位点（变构位点）结合改变其形状，使其不能长时间与底物发生作用。