Tumor cells expressing HSV tk gene can be eradicated by administration of GCV in vitro as well as in vivo.

• 在invitro和invivo水平，表达tk基因的肿瘤细胞均被GCV有效杀伤，这表明HSV－tk/GCV自杀基因系统有可能成为基因治疗脑瘤的有效方法。