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- OBJECTIVE To synthesize Tropisetron hydrochloride and optimize the process. 目的合成盐酸托烷司琼并改进其合成工艺。
- METHODS Tropisetron hydrochloride was synthesized by steps of chlorination, esterification, and hydrochlorination. 方法以3-吲哚甲酸为起始原料,经氯代、酯化、成盐酸反应制得长烷司琼。
- The tropisetron hydrochloride capsules were prepared by different methods with starch as main excipient. 以淀粉为主要填充剂,采用不同工艺制备盐酸托烷司琼胶囊。
- The tropisetron hydrochloride content was determined by HPLC, and the percentage of dissolution was evaluated. 用高效液相色谱法测定其含量,小杯法测定胶囊体外溶出度。
- Conclusion Tropisetron hydrochloride and sodium chloride injection is safe and effective on nausea and vomiting induced by chemotherapy. 结论盐酸托烷司琼氯化钠注射液治疗化疗药物所致恶心、吐安全有效。
- Tropisetron Hydrochloride was synthesized from 1H-indol-3-carboxylic acid by chloride acetylation and condensation with Tropic alcohol. 摘要以3-吲哚甲酸为起始原料，经氯化亚砜酰氯化、与托品醇缩合合成了托烷司琼盐酸盐。
- RESULTS Chemical structure of Tropisetron hydrochloride was confirmed by element analysis,UV,IR, 1HNMR, ESI-MS and EI etc. 结果所得产物经元素分析、紫外光谱、红外光谱、核磁共振谱及质谱等确证了结构。
- Synthesis of antiemetic Tropisetron hydrochloride 止吐药盐酸托烷司琼的合成
- Tropisetron Hydrochloride Tablets 盐酸托烷司琼片
- tropisetron hydrochloride and sodium chloride injection 盐酸托烷司琼氯化钠注射液
- Keywords tropisetron hydrochloride;cisplatin;nausea;vomiting;drug prophylaxis; 托烷司琼;顺铂;恶心;呕吐;药物预防;
- Keywords drug therapy;tropisetron mesylate;tropisetron hydrochloride;cisplatin;doxorubicin;gastrointestinal reaction;nausea;vomiting; 药物疗法;甲磺酸托烷司琼;盐酸托烷司琼（欧必亭）;顺铂;多柔比星;胃肠道反应;恶心;呕吐;
- Keywords Anti-neoplastic combined chemotherapy protocols;Nausea/prevention and control;Vomiting/prevention and control;Tropisetron hydrochloride;Navoban; 抗肿瘤联合化疗方案;恶心/预防和控制;呕吐/预防和控制;盐酸托烷司琼;欧必亭;
- Tropisetron hydrochloride 盐酸托烷司琼
- Dopamine Hydrochloride and Dextrose Inj. 盐酸多巴胺葡萄糖注射液。
- Lidocaine Hydrochloride and Epinephrine Inj. 酸盐利多卡因肾上腺素注射液。
- A trademark used for propoxyphene hydrochloride. 达尔丰用来表示丙氧基氢化物的商标
- Objective To synthesis Sotalol hydrochloride. 合成盐酸索他洛尔。
- Objective:To synthesize bambuterol hydrochloride. 目的:合成盐酸班布特罗。
- Dachuanxiong Hydrochloride for Injection. 注射用大川芎
