Through positive and negative selection, the thymocytes with high avidity for self peptide-MHC complex were eliminated, but retained low but significant reactivity for self-peptides.

• 近年有关外周T细胞群体存活与稳态的深入研究发现:抗原活化前T细胞的存活需要自身肽MHC复合物的作用以提供适度的存活信号;