The systemic exposure of MTX was markedly enhanced by coadministrations of SJ, HHS and rutin, whether given single dose, multiple doses, predoseing or postdosing.

• 大鼠并服单剂量芸香苷、槐花散、及不同给药方式之多剂量槐花，对口服MTX之血药面积及滞留时间皆显著增加。