The recovered hydrogenate has more impurity, so a new purification method was usedwhichsettl-ed the tail peak problem in finished Doxycycline Hyclate.

• 采用向盐酸多西环素精制母液中加5-磺基水杨酸和水的方法,从精制母液中回收出氢化物,并确定了最佳配比。