The expressed Vitreoscilla hemoglobin (VHb) in engineered Escherichia cole of IL-2, TNF and penicillin acylase could improve the cell growth and desired products in the oxygen-limited condition.

• vgb基因的表达产物(Vitreoscilla Hemoglogin,VHb)可促进青霉素酰化酶和TNF、IL-2等基因工程菌在低氧条件下细胞生长和产物表达的状况,由于vgb基因的表达降低了细胞对氧的敏感程度,可望运用它来改善发酵过程中溶氧控制裕度。