The cross-linkage of two IgE molecules by allergen causes mast cells to degranulate, releasing histamine, leukotrienes, and other mediators that perpetuate the airway inflammation.

• 过敏原连接2个IgE分子，使肥大细胞脱颗粒，从而释放组织胺、白细胞素（lenkotrienes）及其他呼吸道炎症的调节因子、IL-5激活并维持嗜酸细胞的数量。