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- Aims: To investigate the killing effects of PNP/fludarabine suicide gene system on human hepatocellular carcinoma cell line BEL7402 in vitro. 目的:研究PNP/fludarabine自杀基因系统对人肝癌细胞系BEL7402的体外杀伤效应。
- Keywords HSVl -tk;Suicide gene system;Hepatoca-rcinoma; 单纯疱疹病毒胸苷激酶基因;自杀基因系统;肝癌;
- The Killing Effect of PNP/fludarabine Suicide Gene System on Human Hepatocellular-carcinoma Cell HepG2 in vitro PNP/fludarabine自杀基因系统对人肝癌细胞HepG2体外杀伤效应
- Treatment of Murine Solid Tumors by HSVtk/GCV Suicide Gene System: An Experimental Research HSVtk/GCV自杀基因系统治疗小鼠实体瘤的实验研究
- PNP/MeP-dR suicide gene system PNP/MeP-dR自杀基因系统
- Suicide gene system 肝癌
- It has been proved that HSV-TK/GCV was the most representative suicide gene therapy system. 研究背景与目的自杀基因治疗是一种重要的肿瘤基因治疗策略,也是肿瘤研究的热点课题之一。
- Study on Killing Effects of Purine Nucleoside Phosphorylase/Fludarabine (PNP/fludarabine) Suicide Gene System on Human Hepatocellular Carcinoma Cell Line BEL7402 in vitro 嘌呤核苷磷酸化酶/氟达拉滨(PNP/fludarabine)自杀基因系统对人肝癌细胞系BEL7402体外杀伤效应的研究
- The Effects of CD &UPRT/5-FC Double Suicide Gene System on Prostate Cancer Cell Was Improved by the Targeted Regulation of Prostate-specific Membrane Antigen Promoter and Enhancer 前列腺特异性膜抗原启动子/增强子靶向调控CD &UPRT/5-FC双自杀基因系统对前列腺癌细胞作用的实验研究
- Con-elusion:The suicide gene therapy system using an ovarian-specific promoter by polyethylenimine mediated transfection has a targeting killing activity on human ovarian cancer. 结论:多聚乙烯基亚胺介导的卵巢特异性启动子调控下的自杀基因对卵巢癌有靶向杀伤作用。
- Repressing effects of double suicide genes system on human cholangiocarcinoma in vivo and in vitro 双自杀基因系统对体内外胆管癌抑制作用的实验研究
- Specific Expression of Suicide Gene in Liver Cancer?Cells Mediated by Adenovirus ?? 腺病毒载体介导的肝癌细胞专一性自杀基因表达
- Including antisense oligonucleotides, ribozymes, at the wrong virus interferents, such as cell suicide gene. 包括反义核苷酸、核酶、缺陷病毒的干扰剂、细胞自杀基因等。
- Objective:To compare the tumor-inhibition effect of ACV and GCV invitro in suicide gene therapy experiment for malignant tumor. 目的 :用含有HSV -TK基因的重组腺病毒/丙氧鸟苷系统(AdTK/GCV)及该重组病毒/无环鸟苷系统(AdTK/ACV) ,在体外分别对4种肿瘤细胞进行抑瘤实验 ,比较GCV、ACV对肿瘤细胞的抑制效果。
- The MIT researchers have previously used an unmodified version of the polymer to selectively deliver a suicide gene to prostate tumors in mice. MIT研究人员曾用一种未修饰的聚合物将一个自杀基因选择性地运送到小鼠的前列腺肿瘤中。
- The former approach is technically simpler in mice but less promising in some ways: for example, cells that undergo silencing of the suicide gene are permanently un-killable. 在小鼠中,前一条途经在技术上较为简单,但是在某些情形下前途有限:例如,自杀基因沉默的细胞永远不能被杀死。
- This review focuses on recent advances in gene therapy for colorectal cancer, including suicide gene, immunotherapy, antiangiogenesis gene and combined therapy. 本文综述了自杀基因、免疫基因、抗肿瘤血管基因及联合治疗大肠癌等最新研究进展。
- Methods:By using RV HSV TK gene system and MTT technique, the growth inhibited effect on myeloma cells with TK gene by GCV were analysed. 方法:应用缺陷型反转录病毒介导的TK基因系统(RV-HSV-TK)转染骨髓瘤细胞,采用细胞增生实验(MTT法),研究更昔洛韦对转染TK基因的骨髓瘤细胞株的抑制作用。
- A synthetic gene network was simulated to investigate the effects of extracellular noise and a periodic signal on the gene system. 摘要采用数值模拟方法,研究了生物信息学中人类遗传因子-基因的转录调控系统。
- Objective To investigate the killing effect of herpes simplex virus thymidine kinase/gancyclovir (HSV tk/GCV) suicide gene therapy system on retinoblastoma (Rb) cells and the mechanism of bystander effect. 目的 研究单纯疱疹病毒胸腺嘧啶核苷激酶 /更昔洛韦 (herpessimplexvirusthymidinekinase /gancyclovir,HSV tk/GCV)自杀基因系统对视网膜母细胞瘤 (retinoblastoma ,Rb)细胞的体外杀伤作用以及旁观者效应发生的机制。
