Starting from 2-bromopropionic acid,tiopronin was synthesized via chloronation,condensation,nucleophilic substitution and deprotection,and the total yield was 47.9 %.

• 以廉价易得的2-溴丙酸为起始原料；依次经过氯代；缩合；亲核取代及脱保护反应制备了硫普罗宁；总收率为35.；7%25。