Sepsis caused by gram negative bacteria infections is one of the mostdangerous causes leading to death in the clinic, and so far the mortalityfrom it has not declined despite the use of supportive therapy and many kindsof antibiotics.

• 革兰氏阴性菌败血症是临床上最常见的致死原因之一，目前所使用的抗生素及对症支持疗法难以有效降低由GNB（Gram Negative Bacteria）败血症休克导致的病死率。