Recently,by taking advantage of the vector-specificity and using gene recombination,small RNA chains,vectors or other microsomes were chemically modified to enhance the tissue-specificity.

• 为了增强对组织靶向性的治疗应用,目前研究有利用载体的特异性及基因重组构建进行调控作用于靶组织,也可以小分子基团特异性化学修饰小RNA双链或载体及其他微粒等方法提高组织靶向性。