Pretreatment of the colonic mucosa with the carbonic anhydrase inhibitor, acetazolamide(1 mmol/L,both sides) did not alter the ofloxacin-induced changes in I_ sc (n=5, P> 0.05 ).

• 结肠黏膜的两侧预先加入碳酸酐酶抑制剂乙酰唑胺(1mmol/L)；对氧氟沙星在结肠上皮产生的效应无显著影响(n=5；P>0.；05);