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- PKC activity was measured with phosphoryl abevacuation . 磷基转移法测定PKC活性变化。
- Actylcholine (Ach) increased particulate and lightly decreased cytosolic PKC activity in both HMC and HMMC, with total PKC activity increase. 乙酰胆碱 (acetylcholine,Ach)可使HMC及HMMC的胞膜PKC比活性升高、胞浆PKC比活性轻度下降、总活性增加 ;
- The activity of PKC could be enhanced by AGEs. Conclusions AGEs can upregulate VCAM-1 expression and PKC activity of HUVECs, and increase adhesion of HUVECs to PBMCs. 蛋白激酶C(PKC)抑制剂可明显降低AGEs所致的VCAM-1表达增加及HUVECs-PBMCs黏附率增加。
- Results With the development of chronic inflammatory PHT, the total and cytosolic fractions of PKC activity in PHT rat pulmonary arteries increased initially with subsequent d... 结论PKC活性的上调和PKC的转位活化可能参与了慢性炎症性肺动脉高压的形成过程。
- When PKC pathway was blocked by PKC inhibitor GF-109203X, cAMP level and PKA activity were increased by 78. 8% and 33. 5% as against that of the control,while the DAG content and PKC activity were decreased by 40.3% and 56.3% respectively. 如用GF－109203X阻断PKC通路时发现cAMP水平与PKA活性分别升高78.;9%25和33
- Interleukin 4 can reverse the multi drug resistance by inhibiting the expression of p gp and increasing the quantity of intracellular chemotherapeutic agents in tumor cells. The effects were probably related to the inhibition of the PKC activity. IL 4可通过抑制肿瘤细胞的p gp表达 ,增加化疗药物在肿瘤细胞内的聚集而逆转白血病细胞的MDR ,此作用可能与?
- Then blood glucose, hemoglobin Alc (HbAlc), glomerular PKC activity, glomerular basement membrane thickness (GBMT) and urine protein/creatinine (Pr/Cr) ratio in diabetic rats were measured and compared with those in the control. 测定糖尿病大鼠血糖、糖化血红蛋白A1c(HbA1c)、PKC活性、肾小球基底膜厚度 (GB MT)和尿蛋白质 肌酐 (Pr Cr)比值 ,并与正常对照组比较。
- Nonenzymatic glycosylation may not directly contribute to increasing PKC activity.Long-term increase of PKC activity may enhance the development and progression of diabetic nephropathy. 结论 高血糖慢性刺激可引起肾小球PKC活性增高，非酶促糖基化可能未直接参与PKC活性改变，PKC活性长期增高可促进糖尿病肾病发生与发展。
- Objective To investigate the effects of 12-lipoxygenase(12-LOX) and its inhibitor, baicalein, on PKC activation in human gastric cancer cell AGS. 目的研究胃癌细胞中蛋白激酶C(PKC)活化与12-脂氧化酶(12-LOX)的关系。
- TPA (12-0-tetradecanoylphorbol 13-acetate), a PKC activator, inhibited the expression of PAX-8 gene stimulated by TSAb, which was reversed by the PKC inhibitior (Calphostin C) . 蛋白激酶C(PKC)激活剂佛波酯(TPA)和抑制剂则无上述效应,TPA抑制TSAb刺激的PAX-8基因的表达,此作用可被PKC抑制剂(Calphostin C)逆转。
- Ha H, Yu MR, Lee HB. High glucose-induced PKC activation mediates TGF-betal and fibronectin synthesis by peritoneal mesothelial cells[J]. Kidney Int , 2001,59(2) :461 470. 黄海长;李惊子;王海燕.;结缔组织生长因子诱导肾成纤维细胞转为成肌纤维细胞[J]
- Thus, our data suggest that the expression of lymphokine receptors of T cells from patienes with active SLE is normal, while the T cells have defiency in receiving the signal derived from PMA, which is possiblly due to the disorder in PKC activation. 因此,这些结果提示:活动性SLE患者在接受PHA刺激后其表达淋巴因子受体无异常,而在接受PMA提供的刺激信号方面有障碍,这可能与其细胞内PKC的活性化功能失调有关。
- Methods Chronic inflammatory PHT was induced in rats with monocrotaline.The PKC activities in the rat pulmonary arteries were measured by radioactive assay during the development of PHT. 方法建立野百合碱诱导的慢性炎症性肺动脉高压大鼠模型，采用同位素标记的放射活性测定法检测肺动脉高压形成过程中肺动脉蛋白激酶C的活性。
- PKC activation and translocation 激活和转位
- The office has been humming with activity. 办公室一直忙着搞活动。
- The threat of war has depressed business activity. 战争的威胁使经济萧条。
- There has been a lot of activity in the town today. 今天市中心相当热闹。
- The town was humming with activity. 该市镇生气勃勃，呈现一片热闹的景象。
- Stamp collecting is my favorite activity. 集邮是我最喜爱的消遣。
- The store was a scene of great activity. 这家商店顾客盈门。
