Our results indicated that small G-protein Rac1 could medicate ligand induced WPB release in HAEC, and the signal pathway of WPB release might be Rac1-dependent ROS regulating mechanism.

• 小G蛋白Rac1介导HAEC凝血酶诱导的WPB的释放。 WPB的释放机制是Rac1依赖的ROS调节过程。