OBJECTIVE:To develop a reversed phase liquid chromatographic method utilizing a single step extraction procedure for the determination of cyclosporin A(CyA) in human whole blood and the study of pharmacokinetics and bioavailability in humans.

• 目的：建立单步萃取?反相高效液相色谱法测定人全血中环孢菌素A（CyA）浓度，研究该药物在人体内的药动学和生物利用度。