More than 30% of various solid tumor types were recently found to have mutations in PIK3CA, the catalytic subunit of PI3K,and the PI3K signaling pathway is deregulated by a variety of mechanisms.

• 研究发现约30%25的人类实体瘤存在PIK3CA基因的突变,导致PI3K信号途径在不同水平发生调控异常。