Mice were randomly divided into three groups, sham operation (C, N=20), UUO (N=40) and UUO with irbesartan treatment (UUO+Irb, N=40).

• 方法:将清洁级、健康雄性CD-1小鼠(10周龄、18-22克)随机分为三大组,假手术组(C,N=20)、单侧输尿管结扎组(UUO,N=40)和Irbesartan干预组(UUO+Irb,N=40)。