Methods: By mircroinjecting 6-OHDA into rat unilateral medial forebrain bundle to induce the damage of unilateral mesencephalic dopamine neurons, a well-known PD rat model was established.

• 方法：用6-羟基多巴胺损毁大鼠单侧中脑黑质多巴胺能神经元、2周后腹腔注射阿朴吗啡诱导大鼠出现偏侧旋转行为的方法制备PD模型大鼠。