Methods The effect of cyclosporin A on the modification of daunorubicin (DNR) accumulation, cytotoxicity, distribution in the resistant K562/ADR was examined by RT-PCR, confocal scanning laser microscopy(CSLM), fluorometry and MTT methods.

• 方法 采用RT- PCR、荧光法、MTT和共聚焦激光扫描显微镜等方法 ,研究 Cs A对柔红霉素 (DNR)在 Pgp耐药细胞株 K5 6 2 /ADR蓄积、毒性及分布的影响。