Methods RIPA, vWF:RCo, vWF:Ag, vWF:CB and multimer assay were developed and various phenotypes were determined on the members of the seven vWD families.

• 方法:自行建立瑞斯托霉素诱导的血小板凝集试验(RIPA)、血管性血友病因子(vWF)瑞斯托霉素辅因子(vWF:RCo)、vWF抗原(vWF:Ag)、vWF胶原结合试验(vWF:CB)和多聚体分析方法,对vWD患者及家系成员进行测定。