Methods 20 Wistar rats were divided into experimental group and control group randomly. The rats administrated DOI by peritoneal injection used as experimental group, and the rats injected with same volume normal saline used as the control group.

• 方法将20只Wistar大鼠随机分为实验组和对照组,实验组大鼠腹腔注射DOI,对照组注射相同体积的生理盐水,连续给药21d。