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- Methods:Lappaconitine hydrobromide (LH) was used as model drug. 方法:以氢溴酸高乌甲素为模型药物,制备适宜的片芯;
- The lappaconitine hydrobromide was synthesized in a new way, with a yield of 84%. 同时用制备方法操作简便,反应条件温和的新方法合成了强镇痛药物刺乌头碱氢溴酸盐,产率可达84%25。
- Lappaconitine hydrobromide can remove inflammation and swelling, lower temperature and relieve heat. 高乌甲素具有抗炎消肿、降温解热与局部麻醉作用。
- And in the lappaconitine hydrobromide preparation, the outgrowth and long reaction time were overcome by dibromine alkyl instead of hydrobromic acid. 同时在氢溴酸盐制备上,用二溴代烷烃代替氢溴酸克服了反应副产物和反应时间长等问题。
- Results:The release of lappaconitine hydrobromide was influenced by the formulation of the core and the thickness and composition of the coating film. 结论:通过调整片芯中崩解剂的用量、包衣层的厚度和组成,可以得到具有不同释药时滞的氢溴酸高乌甲素片剂。
- The structures of extracted lappaconitine and the lappaconitine hydrobromide were characterized by IR, elemental analysis, 1H NMR, 13C NMR and MS. 并用红外光谱、元素分析、核磁谱和质谱等测试技术对刺乌头碱及其氢溴酸盐进行了表征。
- A method for the synthesis of lappaconitine hydrobromide by the reaction of dibromoalkyl with lappaconitine is presented. 报道了以双溴代烷烃和刺乌头碱合成刺乌头碱氢溴酸盐的方法。
- Future efforts should be made in increasing dosage, combining lappaconitine hydrobromide with other drugs and improving drug delivery technique. 今后可从增加剂量、复合其他中西药及改进用药技术等方面继续深入探索,以进一步提高其镇痛效果。
- lappaconitine hydrobromide injection 高乌甲素注射液
- LAPPACONITINE HYDROBROMIDE INJECTION/pharmacology 高鸟甲素注射液/药理学
- The effect and neurotoxication of lumbar anesthesia with lappaconitine hydrobromide in rabbits 高乌甲素的腰麻作用和对神经系统毒性的研究
- Application of lappaconitine hydrobromide combined wit tramadol for postoperative analgesia after thoracic surgery 高乌甲素复合曲马朵用于胸科手术病人术后镇痛疗效观察
- Keywords lappaconitine hydrobromide;absolute configuration;crystal structure;synthesis;characterization; 刺乌头碱氢溴酸盐;绝对构型;晶体结构;合成;表征;
- Keywords lappaconitine;lappaconitine hydrobromide;synthesis;extraction;characterization; 刺乌头碱;刺乌头碱氢溴酸盐;合成;提取;表征;
- Keywords drug incompatibility;drug interactions;glucose;sodium chloride;lappaconitine hydrobromide injection; 药物配伍禁忌;药物相互作用;葡萄糖;氯化钠;氢溴酸高乌甲素;
- Keywords lappaconitine hydrobromide /Pharmacology;small intestine/drug effect;receptor;analgesia; 氢溴酸高乌甲素/药理学;肠肌/药物作用;受体;镇痛;
- Lappaconitine Hydrobromide 溴酸刺乌头碱[强力镇痛剂]
- Dextromethorphan hydrobromide and ibuprofen capsules were determined by HPLC. 用HPLC测定复方胶囊中右美沙芬、布洛芬的溶出度。
- Object: To study the anti inflammatory effect of lappaconitine(LAP). 目的:研究高乌甲素的抗炎作用。
- Why is the content uniformity tested for the scopolamine hydrobromide tablets? 氢溴酸东莨菪碱片含量均匀度检查的意义是什么?
