It was concluded that the EPEC possess the eaeA gene were a main pathogen of diarrhea in rabbit farms in Shandong province and the detection of LEE PAI should be a main method for EPEC molecular diagnosis and epidemiological investigation.

• LEE毒力岛的检测能够作为兔肠致病性大肠杆菌REPEC的诊断和流行病学调查的主要手段。