It is indicated that the expression of E2F1 is increased in the hypertrophic scar and keloid. E2F1 overexpression may play an important role in the proleferation of fibroblasts and in the development of pathological scar.

• E2F1基因在病理性瘢痕组织中增高,促进瘢痕组织中修复效应细胞的增生,对病理性瘢痕的形成可能起着重要作用。