In pancreatic carcinoma most of APE/ref-1 expressed in nuclei and cytoplasm, and normal pancreas tissues, APE/ref-1 was positive in cytoplasm of pancreatic islet cells but negative in pancreatic duct cells and acini.

• 22例癌旁正常胰腺组织导管及腺泡阴性表达仅胰岛的细胞胞浆呈阳性表达。 可见APE/ref-1在胰腺癌多数定位于细胞的胞浆及胞核上,而在癌旁胰腺组织导管及腺泡呈阴性表达仅在胰岛胞浆呈阳性表达。