In order to overcome the immunogenicity of collagenase,the enzyme was modified with monomethoxypolyethylene glycol 5000 (mPEG) activated by p nitrophenyl chloroformate.

• 为解决胶原酶免疫原性，采用经氯甲酸对硝基苯酯活化的单甲氧基聚乙二醇来修饰胶原酶。