In addition, when cotransfected with Fz-7, DEP domain, but not DIX, PDZ or DEP-KM, was translocated and co-localized with Fz-7 to the cytosol plasma as similar as Dvl-1.

• DEP结构域的这种转膜定位与同野生型Dvl-1的膜定位存在明显的竞争关系。