Immunochemical staining in two patients revealed positive reaction for CD68,and negative reaction for AE 1/AE 3,S 100 and HHF 35 .Conclusion Multicentric reticulohistiocytosis is a systematic disease.

• 2例免疫组织化学染色示CD6 8阳性 ; AE1/AE3、S 10 0和HHF35均阴性。