IL 6 and IL 8 levels produced by LPMC fro m involved colons were significantly higher than that from uninvolved colons. Ad ding exogenous anti IL 17 MoAb to LPMC from involved colons resulted in dec rease in IL 6 and IL 8 production.

• 另外 ,UC病变部位LPMC分泌的IL 6和IL 8的水平均明显高于非受累部位的LPMC ,但在培养液中加入抗IL 17单克隆抗体后 ,LPMC细胞IL 6和IL 8的分泌均明显被抑制。