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- Title： Cloning, expression and transcriptional activity of Bm-mof, an MYST histone acetyltransferase gene in the silkworm, Bombyx mori L. 关键词：家蚕;MYST组蛋白乙酰转移酶;克隆;序列分析;表达谱
- This was further supported by the observation that the increasing effect of HS4 was counteracted by histone acetyltransferase inhibitors. 通过加入组蛋白乙酰基转移酶抑制剂，我们观察到HS4的增强作用受到了抑制，这使我们更加确信上述的观点。
- In addition, by using the HAT domain-deleted p300 mutant, weshowed that the histone acetyltransferase activity of p300/CBP was important in regulation ofWT1 gene expression. 此外,通过采用HAT区缺失突变的p300表达质粒的转染实验,我们证明了p300/CBP的组蛋白乙酰转移酶活性在WT1基因转录调控过程中发挥重要作用。
- Taken together, these results significantly advance the understanding of mechanisms that permit fine-tuning of transcriptional regulation by revealing that the hSAGA histone acetyltransferase complex is also capable of histone deubiquitylation. 综上所述,这些结果披露了hSAGA组蛋白乙酰转移酶复合物同时也具有将组蛋白去泛素化的能力,因而大大增进了人们对转录调节过程的精微调节机制的理解。
- Recent studies showed that some transcriptional regulators with histone acetyltransferase(HAT) and deacetylase(HDAC) activities may play a causative role in regulating gene expression. 多种具有组蛋白乙酰化酶(HAT)和组蛋白去乙酰化酶(HDAC)活性的调节因子，通过对组蛋白乙酰化过程的调节，在基因表达调控中发挥着重要作用。
- As a result, we found that the C-terminal fragment of HBO1 (histone acetyltransferase binding to ORC1), an MYST family histone acetyltransferase, interacted with CDK11p58 in yeast. 我们进一步研究发现在体外HAT检测反应体系中直接加入原核表达的CDK11p58纯化蛋白，能显著促进HBO1对的HAT活性；
- For example, histone acetyltransferase (HAT) complexes are thought to activate gene expression by modifying chromatin-associated proteins called histones which function like spools for DNA to wind around. 例如,组蛋白乙酰转移酶(HAT)复合物被认为是通过修饰与染色质相连的被称作组蛋白的蛋白质来激活基因表达的过程,而组蛋白的功能是被当作让DNA缠绕的线轴。
- Keywords Histone acetyltransferase;Histone deacetylase;Cell proliferation;differentiation;Tumor; 组蛋白乙酰化酶;组蛋白去乙酰化酶;细胞增生;分化;肿瘤;
- Roles of Histone Acetyltransferase p300 in ALAS2 Gene Transcription Regulation and the Mechanism by Which Deacetylase Inhibitor Butyrate Activates ALAS2 Gene Transcription 组蛋白乙酰转移酶p300在ALAS2基因转录调控中的作用及组蛋白去乙酰化酶抑制剂丁酸钠激活ALAS2基因转录的机制
- Histone acetyltransferases(HAT) and histone deacetylases(HDACs) as the corresponding enzymes regulate the change of histones in two antagonist forms,acetylated or deacetylated. 组蛋白乙酰转移酶(HAT)和组蛋白去乙酰化酶(HDAC)调节组蛋白乙酰化程度,HDAC在基因表达和染色体形成等方面起着重要的调节作用。
- histone acetyltransferases(HATs) 组蛋白乙酰转移酶（HATs）
- Histone acetyltransferase(HAT ) 组蛋白乙酰转移酶
- MYST histone acetyltransferase MYST组蛋白乙酰转移酶
- Histone acetyltransferase 组蛋白乙酰转移酶
- The histone code will not be easy to crack. 组织蛋白的密码不是那么容易破解的。
- A nucleoprotein whose protein component is a histone. 核组蛋白蛋白成分是组蛋白的核蛋白
- A nucleoprotein whose protein componentis a histone. 核组蛋白蛋白成分是组蛋白的核蛋白。
- Study on histone acetylation in myoblast cultures of DMD chicken embryo. 进行性肌营养不良鸡胚成肌细胞组蛋白的乙酰化研究。
- Histone acetylation/deacetylation is closely related to the regulation of gene. 组蛋白乙酰化/去乙酰化与基因调控密切相关。
- Histone lysine methylation plays a key role in epigenetic regulation. 摘要组蛋白赖氨酸的甲基化在表观遗传调控中起着关键作用。
