Germline E-cadh erin mutations have been found in several familial cases of diffuse gastric canc er and frequent inactivating mutations have been identified for the E-cadherin gene (CDH1) in diffuse gastric cancers.

• 异型增生是一种常见的胃癌癌前病变；为了认识E-cadherin基因在散发性胃癌发展过程中的分子改变；我们对不同地区不同阶段的胃组织标本进行了E-cadherin基因突变的检测.