Following symptoms: rest pain and tissue necrosis, ischemic neuropathy, skin color changes, skin adnexal dystrophy, disuse muscle atrophy and joint stiffness etc.

• 发展后可出现静息痛及组织坏疽、缺血性神经病变、皮肤色泽改变、皮肤附属器营养障碍、废用性肌萎缩及关节僵硬等症状。