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- This regulation of ABCA1 by ATF6 was not through ER stress regulatory pathway. ATF6调节ABCA1与内质网应激信号通路无关.
- ER stress may also be reduced by targeting molecules involved in the UPR process. 此外,还可以通过调控参与UPR过程的分子来降低ER应激反应。
- Conclusions Apoptosis in the AsGnT-V/SMMC-7721 cells induced by ATRA are related to ER stress. 结果GRP78和XBP1的变化表明经ATRA处理后AsGnT-V/SMMC-7721细胞的内质网应激加剧了,而与内质网应激相关的凋亡分子CHOP、caspase-9、caspase-12以及caspase-3都发生了激活。
- Conclusions These results suggested that DMJ could induce cellular ER stress in SMMC7721. caspase-12剪切激活。 结论DMJ可诱导SMMC7721细胞发生内质网应激。
- Currently Boden and his team are looking at whether free fatty acids are a potential cause for this ER stress. 目前Boden和他的研究小组正在研究游离脂肪酸是否也是导致内质网紧张的潜在因素。
- The disorder of calcium iron and accumulation of unfolded protein can lead to ER stress and thus protective unfolded protein response ensure. 内质网中钙离子紊乱和未折叠蛋白质蓄积,可引发内质网应激,发生具有保护作用的未折叠蛋白反应。
- Normal cells respond to ER stress by increasing transcription of genes encoding ER-resident molecular chaperones such as GRP94, GRP78 and PDI to facilitate protein folding. 细胞对这种应激的反应是增加一系列内质网分子伴侣如GRP94、GRP78和PDI等的表达。
- The disorder of calcium ion and the accumulation of unfolded protein can lead to ER stress and thus induce a protective response-unfolded protein response (UPR). 内质网中钙离子紊乱和未折叠蛋白质蓄积可引发内质网应激(endoplasmic reticulum stress, ERS),发生具有保护作用的未折叠蛋白反应(unfolded protein response, UPR)。
- Several studies have suggested that ER stress plays a role in IBD, but the current work also indicates that an inadequate UPR may increase susceptibility. 许多研究认为，内质网压力在IBD有所影响，但目前的研究也指出，不适当的UPR会增加发病可能性。
- In response to this accumulation, called ER stress, the cells activate a repair pathway to fix the problem, either derailing or halting the cell’s death cascade. 这种积累引起的反应，称作内质网应激，应激状态下细胞激活修复信号通路，通过破坏或是终止细胞死亡，去解决折叠中间体积累的问题。
- ER stress involves in neuronal degeneration 内质网应激与神经元退行性变
- Stress can be the undoing of so many fine players. 紧张可能是这许多优秀选手失败的原因。
- Er, let me think. Sorry, my mind's gone blank. 让我想一想。抱歉，我大脑一片空白。
- Er, let me see, it's three dollar all together. 呃，主我想想看，那是总共3美元。
- He will not come until, er, ten o'clock. 他不会在，呃，10点钟以前来的。
- In the word "mother" the stress is on the first syllable. 在"mother"这一字里，重音在第一个音节上。,在＂mother＂这一字里，重音在第一个音节上。
- Doris, er, what do you call her, little Doris? 多丽丝，呃，你叫她什么，小多丽丝？
- Erving. what's he call, er stone? 欧文，他叫什么来着，欧文。斯通？
- He reverted to smoking when under stress. 他因受到压力又恢复了吸烟的习惯。
